All Settings are correct, but the connection times out

It is hard to say the error. I would suggest trying to debug it in a similar fashion as described in this post:

You can check that you can get to the Synology NAS while on the LAN. If you installed remote.it on your Synology NAS and you got an update there might be an issue with the Remote.It install. If you used another computer as a Jumpbox then check that the LAN address for your Synology NAS has not changed.